C₁₂H₈Cl₂N₂O₂*ClH

Base Information

Chemical Name:C₁₂H₈Cl₂N₂O₂*ClH
CAS No.:1426321-22-3
Molecular Formula:C₁₂H₈Cl₂N₂O₂*ClH
Molecular Weight:319.575
Hs Code.:

C<sub>12</sub>H<sub>8</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>*ClH

Synonyms:C₁₂H₈Cl₂N₂O₂*ClH

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Chemical Property of C₁₂H₈Cl₂N₂O₂*ClH

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Technology Process of C₁₂H₈Cl₂N₂O₂*ClH

There total 3 articles about C₁₂H₈Cl₂N₂O₂*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1426320-76-4
6-(3,4-dichloro-phenyl)-5-methyl-pyrimidine-4-carboxylic acid methyl ester

: 1426321-22-3
C₁₂H₈Cl₂N₂O₂*ClH

Guidance literature:: 6-(3,4-dichloro-phenyl)-5-methyl-pyrimidine-4-carboxylic acid methyl ester; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; In acetonitrile; at 80 ℃;

Reference yield:

: 151169-75-4
3,4-dichlophenylboronic acid

: 1426321-22-3
C₁₂H₈Cl₂N₂O₂*ClH

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 16 h / 90 °C / Inert atmosphere

2.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / 50 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

3.2: 80 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1426320-75-3
4-chloro-6-(3,4-dichloro-phenyl)-5-methyl-pyrimidine

: 1426321-22-3
C₁₂H₈Cl₂N₂O₂*ClH

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine / 50 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran / 16 h / 20 °C

2.2: 80 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine; sodium hydroxide; In tetrahydrofuran;