3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid

Base Information

Chemical Name:3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid
CAS No.:256424-00-7
Molecular Formula:C₂₁H₂₁NO₆
Molecular Weight:383.401
Hs Code.:

Synonyms:3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid

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Chemical Property of 3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid

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Technology Process of 3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid

There total 6 articles about 3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 256423-99-1
benzyl 3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoate

: 256424-00-7
3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid

Guidance literature:: With hydrogen; 10percent Pd-C; In 1,4-dioxane; at 20 ℃; for 48h;
DOI:10.1021/jm010978m

Reference yield:

: 10272-07-8
3.5-dimethoxyaniline

: 256424-00-7
3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 82 percent / toluene / 1 h / 20 °C

2.1: POCl₃ / -30 - 75 °C

2.2: 22 percent / aq. AcOH / 3 h / Heating

3.1: 88 percent / Triton B / dimethylformamide / 18 h / 20 °C

4.1: 97 percent / H₂ / 10percent Pd-C / dioxane / 48 h / 20 °C

With hydrogen; N-benzyl-trimethylammonium hydroxide; trichlorophosphate; 10percent Pd-C; In 1,4-dioxane; N,N-dimethyl-formamide; toluene; 3.1: Michael addition;
DOI:10.1021/jm010978m

Reference yield:

: 122172-22-9,29969-62-8
ethyl 2-(4-methoxyphenyl)-2-formyl acetate

: 256424-00-7
3-[5,7-Dimethoxy-3-(4-methoxyphenyl)-2-oxo-1,2-dihydro-1-quinolinyl]propanoic Acid

Guidance literature:: Multi-step reaction with 3 steps

1: 32 percent / polyphosphoric acid trimethylsilyl ester / 1 h / 100 °C

2: 88 percent / Triton B / dimethylformamide / 18 h / 20 °C

3: 97 percent / H₂ / 10percent Pd-C / dioxane / 48 h / 20 °C

With polyphosphoric acid trimethylsilyl ester; hydrogen; N-benzyl-trimethylammonium hydroxide; 10percent Pd-C; In 1,4-dioxane; N,N-dimethyl-formamide; 2: Michael addition;
DOI:10.1021/jm010978m