4-cyclobutylphenol

Base Information

• Chemical Name: 4-cyclobutylphenol
• CAS No.: 10292-59-8
• Molecular Formula: C₁₀H₁₂O
• Molecular Weight: 148.205
• Mol file: 10292-59-8.mol

Synonyms:4-cyclobutylphenol

Chemical Property of 4-cyclobutylphenol

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Cyclobutylphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-cyclobutylphenol

There total 3 articles about 4-cyclobutylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

1-(4-(benzyloxy)phenyl)cyclobutan-1-ol → 4-cyclobutylphenol (10292-59-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 18h; under 2327.23 Torr; Inert atmosphere;

Reference yield:

4-(1,4,5,6-tetrahydro-pyridazin-3-yl)-phenol (28858-18-6) → 4-cyclobutylphenol (10292-59-8)

Guidance literature:

With potassium hydroxide; platinum; at 120 - 180 ℃;

DOI:10.1007/BF00500684

Reference yield:

p-benzyloxyphenylbromide (6793-92-6) → 4-cyclobutylphenol (10292-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine; magnesium / tetrahydrofuran; diethyl ether / 5 h / Reflux

1.2: 2 h / 0 - 20 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 18 h / 20 °C / 2327.23 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; iodine; magnesium; In tetrahydrofuran; diethyl ether; ethanol;

upstream raw materials:

4-(1,4,5,6-tetrahydro-pyridazin-3-yl)-phenol

p-benzyloxyphenylbromide

Refernces

• 1、 -. "DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER". Page/Page column 38. . Retrieved 2016/03/22.
• 2、 -. "HCV POLYMERASE INHIBITORS". Page/Page column 57. . Retrieved 2015/05/05.