2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline

Base Information

Chemical Name:2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline
CAS No.:142643-54-7
Molecular Formula:C₃₂H₃₆N₄O₅
Molecular Weight:556.662
Hs Code.:

Synonyms:2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline

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Chemical Property of 2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline

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Technology Process of 2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline

There total 5 articles about 2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 79476-04-3
(2-quinolyl)trimethylstannane

: 142643-57-0
2-<4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino>pyridyl triflate

: 142643-54-7
2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline

Guidance literature:: With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; for 15h; Heating;
DOI:10.1016/S0040-4020(01)92191-X

Reference yield:

: 131653-62-8
2,2-dimethyl-N-(4-iodo-2-methoxy-3-pyridyl)propanamide

: 142643-54-7
2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / BBr₃ / CH₂Cl₂ / a) -70 deg C, 15 min., b) room temperature, 15 h

2: 91 percent / pyridine / a) 0 deg C, 5 min, b) room temperature, 24 h

3: 75 percent / Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene; H₂O / 12 h / Heating

4: 74 percent / LiCl / Pd(PPh₃)4 / dioxane / 15 h / Heating

With pyridine; boron tribromide; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(01)92191-X

Reference yield:

: 125867-19-8
N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide

: 142643-54-7
2-<2-(4-(3,4-dimethoxy-2-N,N-diethylcarbamoyloxyphenyl)-3-pivaloylamino)pyridyl>quinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 1) n-butyllithium, TMEDA, 2) I₂ / 1) THF, hexane, -10 deg C, 2 h, 2) THF, a) -70 deg C, 15 min., b) -10 deg C, 2 h

2: 80 percent / BBr₃ / CH₂Cl₂ / a) -70 deg C, 15 min., b) room temperature, 15 h

3: 91 percent / pyridine / a) 0 deg C, 5 min, b) room temperature, 24 h

4: 75 percent / Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene; H₂O / 12 h / Heating

5: 74 percent / LiCl / Pd(PPh₃)4 / dioxane / 15 h / Heating

With pyridine; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine; boron tribromide; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(01)92191-X