5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Base Information

Chemical Name:5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione
CAS No.:103788-47-2
Molecular Formula:C₂₂H₁₈N₂O₅S
Molecular Weight:422.461
Hs Code.:

Synonyms:5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Suppliers and Price of 5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

There total 5 articles about 5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 103788-51-8
5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzylidene}-2,4-thiazolidinedione

: 103788-47-2
5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Guidance literature:: With sodium tetrahydroborate; In methanol; N,N-dimethyl-formamide; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00092a012

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 103788-47-2
5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 12 h / Ambient temperature

2: aq. HCOOH / Ra-Ni alloy / 3 h / 100 °C

3: 76 percent / piperidine / ethanol / 9 h / Heating

4: 98 percent / NaBH₄ / dimethylformamide; methanol / 0.17 h / Ambient temperature

With piperidine; sodium tetrahydroborate; formic acid; sodium hydride; Ra-Ni alloy; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a012

Reference yield:

: 2-Hydroxy-1-(5-methyl-2-phenyl-oxazol-4-yl)-ethanone

: 103788-47-2
5-{4-[2-hydroxy-2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 12 h / Ambient temperature

2: aq. HCOOH / Ra-Ni alloy / 3 h / 100 °C

3: 76 percent / piperidine / ethanol / 9 h / Heating

4: 98 percent / NaBH₄ / dimethylformamide; methanol / 0.17 h / Ambient temperature

With piperidine; sodium tetrahydroborate; formic acid; sodium hydride; Ra-Ni alloy; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a012