3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester

Base Information

Chemical Name:3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester
CAS No.:1027586-28-2
Molecular Formula:C₃₇H₃₅IN₂O₅Si
Molecular Weight:742.685
Hs Code.:

Synonyms:3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester

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Chemical Property of 3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester

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Technology Process of 3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester

There total 10 articles about 3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(3-iodo-2-methoxymethoxy-phenyl)-indole-1-carboxylic acid ethyl ester

: 1027586-28-2
3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; dichloromethane; Yield given;
DOI:10.1016/S0040-4039(98)00231-7

Reference yield:

: 61-54-1
tryptamine

: 1027586-28-2
3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: aq. NaOH / dioxane

2: DDQ / tetrahydrofuran; H₂O

3: 1.) thallium tris-trifluoroacetate, TFA, 2.) CuI, I₂ / 2.) DMF

4: HBr / acetic acid

5: diethylphosphoryl cyanide, Et₃N / tetrahydrofuran

6: Ph₃P, Cl₃CCCl₃, Et₃N / CH₂Cl₂

7: Et₃N, DMAP / CH₂Cl₂

8: Pd₂(dba)3*CHCl₃, CuI, Ph₃As, NMP

9: HCl / diethyl ether; methanol; CH₂Cl₂

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium hydroxide; copper(l) iodide; diethylphosphoryl cyanide; hexachloroethane; triphenyl-arsane; hydrogen bromide; iodine; triethylamine; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; thallium(III) trifluoroacetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4039(98)00231-7

Reference yield:

: 38750-13-9
(2-indol-3-yl-ethyl)-carbamic acid benzyl ester

: 1027586-28-2
3-[2-(tert-Butyl-diphenyl-silanyloxymethyl)-oxazol-5-yl]-4-(2-hydroxy-3-iodo-phenyl)-indole-1-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: DDQ / tetrahydrofuran; H₂O

2: 1.) thallium tris-trifluoroacetate, TFA, 2.) CuI, I₂ / 2.) DMF

3: HBr / acetic acid

4: diethylphosphoryl cyanide, Et₃N / tetrahydrofuran

5: Ph₃P, Cl₃CCCl₃, Et₃N / CH₂Cl₂

6: Et₃N, DMAP / CH₂Cl₂

7: Pd₂(dba)3*CHCl₃, CuI, Ph₃As, NMP

8: HCl / diethyl ether; methanol; CH₂Cl₂

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; diethylphosphoryl cyanide; hexachloroethane; triphenyl-arsane; hydrogen bromide; iodine; triethylamine; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; thallium(III) trifluoroacetate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4039(98)00231-7