Technology Process of 4-(2,4-difluorobenzyloxy)-1-(10-methyl-5,6,7,8,9,10-hexahydropyrido[3',2':4,5]pyrrolo[3,2-c]azepin-2-yl)pyridin-2(1H)-one hydrochloride
There total 11 articles about 4-(2,4-difluorobenzyloxy)-1-(10-methyl-5,6,7,8,9,10-hexahydropyrido[3',2':4,5]pyrrolo[3,2-c]azepin-2-yl)pyridin-2(1H)-one hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2,4-difluorobenzyloxy)-1H-pyridin-2-one; tert-butyl 2-bromo-10-methyl-7,8,9,10-tetrahydropyrido[3',2':4,5]pyrrolo[3,2-c]azepine-6(5H)-carboxylate;
With
8-quinolinol; caesium carbonate;
copper(l) iodide;
In
dimethyl sulfoxide;
at 135 ℃;
for 24h;
Inert atmosphere;
With
hydrogenchloride;
In
diethyl ether; dichloromethane;
at 25 ℃;
for 48h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate; 1,10-Phenanthroline / copper(l) iodide / toluene / 18 h / 105 °C / Inert atmosphere
2.1: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 24 h / 135 °C / Inert atmosphere
2.2: 48 h / 25 °C / Inert atmosphere
With
8-quinolinol; 1,10-Phenanthroline; caesium carbonate;
copper(l) iodide;
In
dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: hydrazine / 0.5 h / 70 °C
2.1: diethyl ether / 1 h / 20 °C
3.1: toluene-4-sulfonic acid / 0.42 h / 160 °C
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / water; tetrahydrofuran / 5 h
5.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere
6.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 4 h / Reflux
7.1: diphenyl phosphoryl azide / 8 h / 100 °C
7.2: pH 7
8.1: borane-THF / tetrahydrofuran / 18 h / Reflux
8.2: Reflux
8.3: 18 h / 20 °C / Inert atmosphere
9.1: caesium carbonate; 8-quinolinol / copper(l) iodide / dimethyl sulfoxide / 24 h / 135 °C / Inert atmosphere
9.2: 48 h / 25 °C / Inert atmosphere
With
8-quinolinol; borane-THF; diphenyl phosphoryl azide; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; hydrazine;
copper(l) iodide;
In
tetrahydrofuran; diethyl ether; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
