3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide

Base Information

Chemical Name:3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide
CAS No.:1262776-28-2
Molecular Formula:C₁₇H₁₅FN₂O₃
Molecular Weight:314.316
Hs Code.:

Synonyms:3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide

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Chemical Property of 3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide

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Technology Process of 3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide

There total 4 articles about 3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₂₂H₂₃FN₂O₄

: 1262776-28-2,852475-26-4
3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 21 ℃; for 1h;
DOI:10.1021/jm401945k

Reference yield:

: 60730-21-4
ethyl 3-(1-methyl-1H-pyrrol-2-yl)-2-propenoate

: 1262776-28-2,852475-26-4
3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / 0.75 h / 0 °C

1.2: 0.23 h / 100 °C / Microwave irradiation

2.1: barium hydroxide octahydrate; methanol / 0.25 h / 21 °C

2.2: 0.5 h / 40 °C / Microwave irradiation

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 21 °C

4.1: toluene-4-sulfonic acid / methanol / 1 h / 21 °C

With methanol; oxalyl dichloride; barium hydroxide octahydrate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm401945k

Reference yield:

: ethyl 3-(5-formyl-1-methyl-1H-pyrrol-2-yl)-2-propenoate

: 1262776-28-2,852475-26-4
3-(5-(3-(3-fluorophenyl)-3-oxo-1-propen-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: barium hydroxide octahydrate; methanol / 0.25 h / 21 °C

1.2: 0.5 h / 40 °C / Microwave irradiation

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 16 h / 21 °C

3.1: toluene-4-sulfonic acid / methanol / 1 h / 21 °C

With methanol; barium hydroxide octahydrate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm401945k