C₂₅H₂₇F₃N₄O₃

Base Information

• Chemical Name: C₂₅H₂₇F₃N₄O₃
• CAS No.: 1537880-28-6
• Molecular Formula: C₂₅H₂₇F₃N₄O₃
• Molecular Weight: 488.51
• Mol file: 1537880-28-6.mol

Synonyms:C₂₅H₂₇F₃N₄O₃

Chemical Property of C₂₅H₂₇F₃N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₇F₃N₄O₃

There total 5 articles about C₂₅H₂₇F₃N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (3aR,5R,6aR)-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylate (1537879-99-4) → C25H27F3N4O3 (1537880-28-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: potassium hydroxide / tetrahydrofuran; water

3: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran

4: trifluoroacetic acid / dichloromethane

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.bmcl.2013.05.024

Reference yield:

methyl (3aR,5R,6aR)-2-benzyl-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylate (1443232-24-3) → C25H27F3N4O3 (1537880-28-6)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen; palladium(II) hydroxide / methanol / 20 °C / 1292.9 Torr

2: triethylamine / dichloromethane / 0 - 20 °C

3: potassium hydroxide / tetrahydrofuran; water

4: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran

5: trifluoroacetic acid / dichloromethane

With hydrogen; palladium(II) hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1016/j.bmcl.2013.05.024

Reference yield:

(3aR,5R,6aR)-2-((benzyloxy)carbonyl)-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylic acid (1537880-03-7) → C25H27F3N4O3 (1537880-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran

2: trifluoroacetic acid / dichloromethane

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2013.05.024

upstream raw materials:

methyl (3aR,5R,6aR)-2-benzyl-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylate

methyl (3aR,5R,6aR)-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylate

(3aR,5R,6aR)-2-benzyl 3a-methyl 5-((tert-butoxycarbonyl)amino)hexahydrocyclopenta[c]pyrrole-2,3a(1H)-dicarboxylate

(3aR,5R,6aR)-2-((benzyloxy)carbonyl)-5-((tert-butoxycarbonyl)amino)octahydrocyclopenta[c]pyrrole-3a-carboxylic acid

Downstream raw materials:

(3aR,5R,6aR)-benzyl 5-((3-methoxytetrahydro-2H-pyran-4-yl)amino)-3a-(3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carbonyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate