1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole

Base Information

• Chemical Name: 1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole
• CAS No.: 1332525-29-7
• Molecular Formula: C₁₇H₁₃N₅OS
• Molecular Weight: 335.389
• Mol file: 1332525-29-7.mol

Synonyms:1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole

Chemical Property of 1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole

There total 1 articles about 1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-(benzylsulfanyl)pyrimidin-4(3H)-one (31167-21-2) + (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (56602-33-6) → 1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole (1332525-29-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 25 ℃; for 3h;

DOI:10.1039/c4ob02235a

Reference yield: 97.0%

4-benzyloxybenzyl alcohol (836-43-1) + 1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole (1332525-29-7) → 4-[4-(benzyloxy)benzyloxy]-2-(benzylsulfanyl)pyrimidine

Guidance literature:

With potassium tert-butylate; In acetonitrile; at 25 ℃; for 1.5h;

DOI:10.1039/c4ob02235a

Reference yield:

1-[2-(benzylsulfanyl)pyrimidin-4-yloxy]-1H-[b]-[1,2,3]-benzotriazole (1332525-29-7) → 4-[4-(benzyloxy)benzyloxy]-2-(benzylsulfonyl)pyrimidine

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / acetonitrile / 1.5 h / 25 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 25 °C / Cooling with ice

With potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c4ob02235a

upstream raw materials:

2-(benzylsulfanyl)pyrimidin-4(3H)-one

(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate