2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate

Base Information

Chemical Name:2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate
CAS No.:80127-26-0
Molecular Formula:C₁₉H₁₉ClN₂O₄S
Molecular Weight:406.89
Hs Code.:

Synonyms:2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate

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Chemical Property of 2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate

There total 4 articles about 2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 80127-25-9
(2S,5R,6R)-3,3-Dimethyl-4,7-dioxo-6-phenylacetylamino-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2-chloro-allyl ester

: 80127-26-0
2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate

Guidance literature:: With pyridine; phosphoric acid; In 1,4-dioxane; for 5h; Heating;
DOI:10.1021/jo00342a048

Reference yield:

: 113-98-4
Penicillin G potassium

: 80127-26-0
2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / sodium iodide / dimethylformamide / 20 h / 25 °C

2: m-chloroperbenzoic acid (MCPBA) / CH₂Cl₂

3: 54 percent / 85percent phosphoric acid, pyridine / dioxane / 5 h / Heating

With pyridine; phosphoric acid; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00342a048

Reference yield:

: 76627-82-2
2-chloro-2-propenyl (3S,5R,6R)-2,2-dimethyl-6-(phenylacetamido)-7-oxopenam-3-carboxylate

: 80127-26-0
2-chloro-2-propenyl (6R,7R)-3-methyl-7-(phenylacetamido)-8-oxo-3-cephem-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid (MCPBA) / CH₂Cl₂

2: 54 percent / 85percent phosphoric acid, pyridine / dioxane / 5 h / Heating

With pyridine; phosphoric acid; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jo00342a048