ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate
CAS No.:1124173-45-0
Molecular Formula:C₂₄H₂₅F₂N₅O₅
Molecular Weight:501.49
Hs Code.:

Synonyms:ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate

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Chemical Property of ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate

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Technology Process of ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate

There total 1 articles about ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 4-(5-(2-hydrazinyl-2-oxoacetamido)pyridin-2-yloxy)methylcyclohexanecarboxylate

: 113028-75-4
3,4-difluorophenyl isothiocyanate

: 1124173-45-0
ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate

Guidance literature:: ethyl 4-(5-(2-hydrazinyl-2-oxoacetamido)pyridin-2-yloxy)methylcyclohexanecarboxylate; 3,4-difluorophenyl isothiocyanate; In N,N-dimethyl-formamide; at 40 - 80 ℃; for 0.75h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 80 ℃; for 1.5h;

Reference yield: 9.9%

: 1124173-45-0
ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate

: (1r,4r)-4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylic acid

Guidance literature:: ethyl 4-(5-(5-(3,4-difluorophenylamino)-1,3,4-oxadiazole-2-carboxamido)pyridin-2-yloxy)-1-methylcyclohexanecarboxylate; With potassium trimethylsilonate; In tetrahydrofuran; at 90 ℃; for 0.333333h; Sealed tube; Microwave irradiation;

With water; In tetrahydrofuran;