(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

Base Information

Chemical Name:(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one
CAS No.:203926-61-8
Molecular Formula:C₄₇H₆₂O₇Si₂
Molecular Weight:795.176
Hs Code.:

(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

Synonyms:(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

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Chemical Property of (2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

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Technology Process of (2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

There total 11 articles about (2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135265-40-6
(2R,3R)-4-(4-Methoxy-benzyloxy)-3-methyl-butane-1,2-diol

: 203926-61-8
(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / N-p-toluenesulfonyl imidazole, NaH / tetrahydrofuran

2: 87 percent / BF₃*Et₂O

3: TBAF / tetrahydrofuran

4: Et₃N

5: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 40 min

With n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-tosylimidazole; In tetrahydrofuran;
DOI:10.1021/ja973286p

Reference yield:

: 135265-42-8
(R)-2-[(R)-2-(4-Methoxy-benzyloxy)-1-methyl-ethyl]-oxirane

: 203926-61-8
(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / BF₃*Et₂O

2: TBAF / tetrahydrofuran

3: Et₃N

4: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 40 min

With n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran;
DOI:10.1021/ja973286p

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 203926-61-8
(2S,5R,10S,11R)-5-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-12-(4-methoxy-benzyloxy)-11-methyl-10-trimethylsilanyloxy-dodec-7-yn-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: 75 percent / NaH, TBAI / tetrahydrofuran

2: 80 percent / methanolic p-TsOH

3: 87 percent / N-p-toluenesulfonyl imidazole, NaH / tetrahydrofuran

4: 87 percent / BF₃*Et₂O

5: TBAF / tetrahydrofuran

6: Et₃N

7: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, -78 deg C, 40 min

With n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; triethylamine; N-tosylimidazole; In tetrahydrofuran;
DOI:10.1021/ja973286p