(R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Base Information

Chemical Name:(R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester
CAS No.:96864-03-8
Molecular Formula:C₂₈H₄₉NO₄S
Molecular Weight:495.767
Hs Code.:

Synonyms:(R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Chemical Property:

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Technology Process of (R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

There total 1 articles about (R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 96864-31-2
<(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl>propionate

: 106-94-5
propyl bromide

: 96864-03-8
(R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃;
DOI:10.1002/hlca.19850680126

Reference yield:

: 96864-03-8
(R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 105-30-6,17092-41-0,17092-54-5,17092-42-1
(S)-2-methyl-1-pentanol

: 96303-88-7
(-)-10-dicyclohexylsulfamoyl-D-isoborneol

: 105-30-6,17092-42-1,17092-54-5,17092-41-0
(R)-2-methylpentan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 0.5h;
DOI:10.1002/hlca.19850680126

Reference yield:

: 96864-03-8
(R)-2-Methyl-pentanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

: 104897-87-2
(S)-3-Methyl-hexanoic acid (1S,2R,4R)-1-[(dicyclohexylsulfamoyl)-methyl]-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: LiAlH₄ / diethyl ether / 0.5 h / 0 - 20 °C

2: AgCN / benzene / 4 h / Heating

3: 1.) CuI*P(Bu)3; 2.) BF₃*Et₂O / 1.) -78 deg C, 30 min, Et₂O; 2.) Et₂O-THF (4:1) -78 to -40 deg C, 20 h

With lithium aluminium tetrahydride; silver cyanide; CuI*P(n-Bu)3; boron trifluoride diethyl etherate; In diethyl ether; benzene;
DOI:10.1002/hlca.19850680126