(+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol

Base Information

• Chemical Name: (+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol
• CAS No.: 702684-35-3
• Molecular Formula: C₁₇H₁₉NO₂
• Molecular Weight: 269.343
• Mol file: 702684-35-3.mol

Synonyms:(+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol

Chemical Property of (+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol

There total 1 articles about (+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methoxy-6-methyl-benzaldehyde (54884-55-8) + (2S)-2-phenylglycinol (20989-17-7) → (+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol (702684-35-3)

Guidance literature:

With 4A MS; In ethanol; at 20 ℃; for 26h;

DOI:10.1002/hlca.200490054

Reference yield: 67.0%

methyllithium (917-54-4) + (+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol (702684-35-3) → (+)-(βS)-β-{[(1S)-1-(2-methoxy-6-methylphenyl)ethyl]amino}benzeneethanol (702684-36-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -78 ℃; for 48h;

DOI:10.1002/hlca.200490054

Reference yield:

(+)-(βS)-β-{[(1E)-(2-methoxy-6-methylphenyl)methylene]amino}benzeneethanol (702684-35-3) → (-)-[(1S)-1-(2-methoxy-6-methylphenyl)ethyl]amine (702684-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / tetrahydrofuran; diethyl ether / 48 h / -78 °C

2: 5.30 g / K₂CO₃; Pb(OAc)4 / methanol; CH₂Cl₂ / 0 °C

3: 2.38 g / aq. HCl / CH₂Cl₂ / 15 h / 20 °C

With lead(IV) acetate; hydrogenchloride; potassium carbonate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

DOI:10.1002/hlca.200490054

upstream raw materials:

2-methoxy-6-methyl-benzaldehyde

(2S)-2-phenylglycinol

Downstream raw materials:

(+)-(βS)-β-{[(1S)-1-(2-methoxy-6-methylphenyl)ethyl]amino}benzeneethanol

(-)-[(1S)-1-(2-methoxy-6-methylphenyl)ethyl]amine