(R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

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Chemical Name:(R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol
CAS No.:1426532-77-5
Molecular Formula:C₄₀H₃₃F₃N₂O
Molecular Weight:614.71
Hs Code.:

Synonyms:(R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

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Chemical Property of (R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

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Technology Process of (R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

There total 4 articles about (R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1426532-71-9
(R)-(2-bromoquinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1426532-77-5
(R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In ethanol; water; toluene; at 105 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ol400150z

Reference yield:

: 628292-12-6
(2S)-1-triphenylmethyl-2-pyrrolidinemethanal

: 1426532-77-5
(R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 24 h / 105 °C / Inert atmosphere

With TurboGrignard; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; ethanol; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1021/ol400150z

Reference yield:

: 179918-60-6
(2S)-1-triphenylmethyl-2-pyrrolidinemethanol

: 1426532-77-5
(R)-(2-(4-(trifluoromethyl)phenyl)quinolin-4-yl)((S)-1-tritylpyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

1.2: 1.5 h / -78 °C / Inert atmosphere

2.1: TurboGrignard / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 24 h / 105 °C / Inert atmosphere

With TurboGrignard; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; caesium carbonate; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 3.1: |Suzuki Coupling;
DOI:10.1021/ol400150z