(1R,2R,R_S)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane

Base Information

• Chemical Name: (1R,2R,R_S)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane
• CAS No.: 648908-26-3
• Molecular Formula: C₃₂H₄₂ClNO₂S
• Molecular Weight: 540.21
• Mol file: 648908-26-3.mol

Synonyms:(1R,2R,R_S)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane

Chemical Property of (1R,2R,R_S)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R,R_S)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane

There total 1 articles about (1R,2R,R_S)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

[4-(benzylideneamino)phenyl]methanol (783-08-4) + 1-chloroundecyl p-tolyl sulfoxide → (1R,2R,RS)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane (648908-26-3)

Guidance literature:

1-chloroundecyl p-tolyl sulfoxide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.166667h;

[4-(benzylideneamino)phenyl]methanol; In tetrahydrofuran; at -78 ℃; for 0.5h;

DOI:10.1016/j.tet.2003.09.025

Reference yield: 94.0%

(1R,2R,RS)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane (648908-26-3) → (2R,3R,RS)-2-decyl-1-(4-methoxyphenyl)-3-phenyl-2-(p-tolylsulfinyl)aziridine (648908-29-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 70 ℃; for 0.666667h;

DOI:10.1016/j.tet.2003.09.025

Reference yield:

(1R,2R,RS)-2-chloro-1-(4-methoxyphenylamino)-1-phenyl-2-(p-tolylsulfinyl)dodecane (648908-26-3) → (S)-1-Benzyl-undecylamine

Guidance literature:

Multi-step reaction with 4 steps

1.1: 94 percent / t-BuOK / tetrahydrofuran / 0.67 h / 70 °C

2.1: EtMgBr / tetrahydrofuran / -78 - 20 °C

2.2: 97 percent / NH₄Cl; water

3.1: H₂ / Pd(OH)2/C / methanol; ethyl acetate

4.1: cerium(IV) ammonium nitrate / acetonitrile; H₂O / 2.5 h / 0 - 20 °C

With ammonium cerium(IV) nitrate; ethylmagnesium bromide; potassium tert-butylate; hydrogen; palladium dihydroxide; In tetrahydrofuran; methanol; water; ethyl acetate; acetonitrile;

DOI:10.1016/j.tet.2003.09.025

upstream raw materials:

[4-(benzylideneamino)phenyl]methanol

Downstream raw materials:

(2R,3R,R_S)-2-decyl-1-(4-methoxyphenyl)-3-phenyl-2-(p-tolylsulfinyl)aziridine

(S)-N-(1-benzylundecyl)acetamide

(S)-N-(1-benzyl-1-deuterioundecyl)acetamide

(S)-(+)-N-(1-benzyl-1-methylundecyl)acetamide