2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine

Base Information

• Chemical Name: 2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine
• CAS No.: 199452-33-0
• Molecular Formula: C₁₆H₁₈BrN₃O₂
• Molecular Weight: 364.242
• Mol file: 199452-33-0.mol

Synonyms:2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine

Chemical Property of 2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine

There total 4 articles about 2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzyl-methyl-amine (103-67-3) + 6-Bromo-5-methyl-8-nitro-1,4-dihydro-benzo[d][1,3]oxazin-2-one (186267-77-6) → 2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine (199452-33-0)

Guidance literature:

for 8h; Heating;

DOI:10.1021/jo9707491

Reference yield:

2-amino-6-methylbenzyl alcohol (65658-16-4) → 2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine (199452-33-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 94 percent / Et₃N / tetrahydrofuran; toluene / 16 h / Ambient temperature

2: 94 percent / Br₂ / acetic acid; trifluoroacetic acid / 5 h

3: 99 percent / conc. H₂SO₄, KNO₃ / 18 h / Ambient temperature

4: 70 percent / 8 h / Heating

With sulfuric acid; bromine; potassium nitrate; triethylamine; In tetrahydrofuran; acetic acid; toluene; trifluoroacetic acid;

DOI:10.1021/jo9707491

Reference yield:

6-Bromo-5-methyl-8-nitro-1,4-dihydro-benzo[d][1,3]oxazin-2-one (186267-77-6) → 2-[(Benzyl-methyl-amino)-methyl]-4-bromo-3-methyl-6-nitro-phenylamine (199452-33-0)

Guidance literature:

upstream raw materials:

benzyl-methyl-amine

6-Bromo-5-methyl-8-nitro-1,4-dihydro-benzo[d][1,3]oxazin-2-one

2-amino-6-methylbenzyl alcohol

5-methyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one