(6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

Base Information

Chemical Name:(6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester
CAS No.:341508-58-5
Molecular Formula:C₂₄H₃₇N₃O₆
Molecular Weight:463.574
Hs Code.:

Synonyms:(6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

Suppliers and Price of (6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

There total 6 articles about (6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 286965-03-5
(6S)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohex-4-eneoylglycine ethyl ester

: 341508-58-5
(6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 5.5h; under 1810.07 Torr;
DOI:10.1021/jo001308b

Reference yield:

: 286965-00-2
(6S)-6-benzyl-6-[N-(tert-butoxycarbonyl)]-hex-4-enoic acid ethyl ester

: 341508-58-5
(6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: TFA / CH₂Cl₂ / 1 h / 20 °C

2: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; Et₃N; HOBt / 20 °C

3: 77 percent / LiOH / tetrahydrofuran; H₂O / 0 - 20 °C

4: 84 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; Et₃N; HOBt / 20 °C

5: H₂ / Pd/C / ethyl acetate / 5.5 h / 1810.07 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo001308b

Reference yield:

: 286965-01-3
(6S)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohex-4-enoic acid ethyl ester

: 341508-58-5
(6R)-6-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl]aminohexanoylglycine ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / LiOH / tetrahydrofuran; H₂O / 0 - 20 °C

2: 84 percent / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; Et₃N; HOBt / 20 °C

3: H₂ / Pd/C / ethyl acetate / 5.5 h / 1810.07 Torr

With lithium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/jo001308b