4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester

Base Information

• Chemical Name: 4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester
• CAS No.: 3496-05-7
• Molecular Formula: C₁₃H₂₁O₆PS
• Molecular Weight: 336.346
• Mol file: 3496-05-7.mol

Synonyms:4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester

Chemical Property of 4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester

There total 4 articles about 4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromomethyl-benzenesulfonic acid methyl ester (89980-97-2) + triethyl phosphite (122-52-1) → 4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester (3496-05-7)

Guidance literature:

for 1h; Inert atmosphere; Reflux;

DOI:10.1021/ja306162g

Reference yield:

methyl p-toluene sulfonate (80-48-8) → 4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester (3496-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / N-bromosuccinimide; HCl / CCl₄ / 4 h / Heating

2: 27 percent / Heating

With hydrogenchloride; N-Bromosuccinimide; In tetrachloromethane; 2: Michaelis-Arbuzov reaction;

DOI:10.1021/jo050507y

Reference yield:

4-(bromomethyl)benzene-1-sulfonyl chloride (66176-39-4) → 4-(diethoxy-phosphorylmethyl)-benzenesulfonic acid ethyl ester (3496-05-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; methanol / -78 - 20 °C

2: 1 h / Inert atmosphere; Reflux

In tetrahydrofuran; methanol; 2: |Arbuzov Reaction;

DOI:10.1021/ja306162g

upstream raw materials:

4-bromomethyl-benzenesulfonic acid methyl ester

triethyl phosphite

methyl p-toluene sulfonate

4-(bromomethyl)benzene-1-sulfonyl chloride

Downstream raw materials:

ethyl 4-((E)-4-((E)-4-cyanostyryl)styryl)benzenesulfonate