{[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid

Base Information

• Chemical Name: {[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid
• CAS No.: 142824-68-8
• Molecular Formula: C₂HF₃O₂*C₄₂H₄₆F₅N₅O₈S₂
• Molecular Weight: 1022

Synonyms:{[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid

Chemical Property of {[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid

There total 6 articles about {[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1⁽²¹⁾,18⁽²²⁾,19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,4-bis(bromomethyl)benzene (623-24-5) → {[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1(21),18(22),19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid (142824-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 54 percent / Cs₂CO₃ / dimethylformamide

2: aq. 1 M KOH / dimethylformamide

3: DCC / dimethylformamide

4: water

With potassium hydroxide; water; caesium carbonate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)79854-6

Reference yield:

Nα-tert-butoxycarbonyl-Nε-tosyl-L-lysine (13734-29-7) → {[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1(21),18(22),19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid (142824-68-8)

Guidance literature:

Multi-step reaction with 5 steps

1: DIPEA/DCC/HOBt / dimethylformamide

2: 54 percent / Cs₂CO₃ / dimethylformamide

3: aq. 1 M KOH / dimethylformamide

4: DCC / dimethylformamide

5: water

With potassium hydroxide; water; benzotriazol-1-ol; caesium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)79854-6

Reference yield:

Boc-Lys(Ts)-Lys(Ts)-Gly-OMe (142824-65-5) → {[(8R,11R)-11-Amino-10-oxo-3,16-bis-(toluene-4-sulfonyl)-3,9,16-triaza-bicyclo[16.2.2]docosa-1(21),18(22),19-triene-8-carbonyl]-amino}-acetic acid pentafluorophenyl ester; compound with trifluoro-acetic acid (142824-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 54 percent / Cs₂CO₃ / dimethylformamide

2: aq. 1 M KOH / dimethylformamide

3: DCC / dimethylformamide

4: water

With potassium hydroxide; water; caesium carbonate; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)79854-6

upstream raw materials:

trifluoroacetic acid

1,4-bis(bromomethyl)benzene

N^α-tert-butoxycarbonyl-N^ε-tosyl-L-lysine

Boc-Lys(Ts)-Lys(Ts)-Gly-OMe

Downstream raw materials:

C₇₂H₉₀N₁₀O₁₄S₄

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