2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol

Base Information

• Chemical Name: 2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol
• CAS No.: 108817-09-0
• Molecular Formula: C₃₁H₃₈O₃
• Molecular Weight: 458.641
• Mol file: 108817-09-0.mol

Synonyms:2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol

Chemical Property of 2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol

There total 9 articles about 2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-(3-bromo-5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol → 2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol (108817-09-0)

Guidance literature:

With potassium hydroxide; hydrogen; nickel; In methanol; Ambient temperature;

DOI:10.1016/S0040-4020(01)96103-4

Reference yield: 75.0%

2-<3-(3-bromo-5-methylsalicyl)-5-tert-butylsalicyl>-4-cyclohexylphenol (108817-05-6) → 2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol (108817-09-0)

Guidance literature:

With potassium hydroxide; hydrogen; nickel; In methanol; under 760 Torr;

DOI:10.1021/jo00391a005

Reference yield:

p-cyclohexylphenol (1131-60-8) → 2-(5-cyclohexyl-2-hydroxybenzyl)-4-t-butyl-6-(2-hydroxy-5-methylbenzyl)-phenol (108817-09-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 5 h / 130 °C

2: 75 percent / H₂, KOH / Raney Ni / methanol / 760 Torr

With potassium hydroxide; hydrogen; nickel; In methanol;

DOI:10.1021/jo00391a005

upstream raw materials:

2-<3-(3-bromo-5-methylsalicyl)-5-tert-butylsalicyl>-4-cyclohexylphenol

2-(3-bromo-5-methylsalicyl)-4-tert-butylphenol

2-(3-bromo-5-methylsalicyl)-4-tert-butyl-6-(bromomethyl)phenol

p-cyclohexylphenol

Downstream raw materials:

C₄₂H₄₈O₆

5-methyl-11-tert-butyl-17-cyclohexyl-23-octyl-25,26,27,28-tetrahydrocalix<4>arene

C₄₅H₄₈O₄