tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate

Base Information

• Chemical Name: tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate
• CAS No.: 246039-15-6
• Molecular Formula: C₃₀H₄₁N₇O₉
• Molecular Weight: 643.697

Synonyms:tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate

Chemical Property of tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate

Chemical Property:

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Technology Process of tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate

There total 3 articles about tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

isobutyryl chloride (79-30-1) + tert-butyl 7-[2-amino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate (246039-13-4) → tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate (246039-15-6)

Guidance literature:

In pyridine; at 20 ℃;

DOI:10.1016/S0040-4020(99)00541-4

Reference yield:

2-hydroxynitrobenzene (88-75-5,78813-12-4) → tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate (246039-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / DABCO; Et₃N / 1,2-dichloro-ethane / 20 °C

2: 93 percent / pyridine / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In pyridine; 1,2-dichloro-ethane; 1: Substitution / 2: Acylation;

DOI:10.1016/S0040-4020(99)00541-4

Reference yield:

tert-butyl 7-(2-amino-6-chloropurin-9-yl)-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate (246039-12-3) → tert-butyl 7-[2-isobutyrylamino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate (246039-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / DABCO; Et₃N / 1,2-dichloro-ethane / 20 °C

2: 93 percent / pyridine / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In pyridine; 1,2-dichloro-ethane; 1: Substitution / 2: Acylation;

DOI:10.1016/S0040-4020(99)00541-4

upstream raw materials:

isobutyryl chloride

tert-butyl 7-[2-amino-6-(2-nitrophenoxy)purin-9-yl]-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate

2-hydroxynitrobenzene

tert-butyl 7-(2-amino-6-chloropurin-9-yl)-5S-[N-(tert-butoxycarbonyl)amino]-3-oxaheptanate

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