2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester

Base Information

Chemical Name:2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester
CAS No.:1476070-61-7
Molecular Formula:C₂₅H₂₇F₃N₄O₁₁
Molecular Weight:616.505
Hs Code.:

Synonyms:2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester

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Chemical Property of 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester

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Technology Process of 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester

There total 7 articles about 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1476070-55-9
C₂₃H₂₈N₄O₁₀

: 407-25-0
trifluoroacetic anhydride

: 1476070-61-7
2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester

Guidance literature:: In pyridine; at 0 ℃; for 1h;
DOI:10.1080/15257770.2013.838261

Reference yield:

: 1476070-51-5
glycine 2-(p-nitrophenyl)ethyl ester hydrochloride

: 1476070-61-7
2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 20 °C

2: pyridine / 1 h / 0 °C

With triethylamine; In pyridine;
DOI:10.1080/15257770.2013.838261

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 1476070-61-7
2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetylglycine 2-(p-nitrophenyl)ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexyl-carbodiimide / acetonitrile; pyridine / 12 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C

3: triethylamine / 20 °C

4: pyridine / 1 h / 0 °C

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In 1,4-dioxane; pyridine; acetonitrile;
DOI:10.1080/15257770.2013.838261