2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

Base Information

Chemical Name:2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole
CAS No.:863561-65-3
Molecular Formula:C₃₇H₅₀N₄O₃S
Molecular Weight:630.895
Hs Code.:

2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

Synonyms:2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

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Chemical Property of 2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

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Technology Process of 2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

There total 5 articles about 2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 5382-16-1
4-HYDROXYPIPERIDINE

: C₃₂H₄₁N₃O₃S

: 863561-65-3
2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 666852-63-7
ethyl 2-methyl-2-(2-thienyl)propanoate

: 863561-65-3
2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

Guidance literature:: Multi-step reaction with 11 steps

1.1: nitronium tetrafluoborate / 1,2-dimethoxyethane / 4 h / -55 - -10 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 5 h / 1140.08 Torr

3.1: tetrahydrofuran / 16 h / Heating / reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 10 - 20 °C

4.2: -5 - 20 °C

5.1: zinc(II) chloride / iso-butanol / 8 h / 100 °C

6.1: sodium hydroxide; water / ethanol / 4 h / 60 °C

6.2: 5 °C / pH 1

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2.25 h / 0 - 20 °C

8.1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

9.1: triethylamine; sodium iodide / ISOPROPYLAMIDE / 4 h / 110 °C

10.1: sodium hydroxide; water / ethanol / 2 h / 60 °C

11.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.5 h / 20 °C

With sodium hydroxide; thionyl chloride; nitronium tetrafluoborate; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; zinc(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; ISOPROPYLAMIDE; ethyl acetate; N,N-dimethyl-formamide; iso-butanol;

Reference yield:

: 666852-64-8
ethyl 2-methyl-2-(5-nitro-2-thienyl)propanoate

: 863561-65-3
2-[1,1-dimethyl-2-oxo-2-(7-azabicyclo[2.2.1]heptan-7-yl)ethyl]-4-[2-(4-{4-hydroxypiperidin-1-ylcarbonyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2.3-b]pyrrole

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 5 h / 1140.08 Torr

2.1: tetrahydrofuran / 16 h / Heating / reflux

3.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 10 - 20 °C

3.2: -5 - 20 °C

4.1: zinc(II) chloride / iso-butanol / 8 h / 100 °C

5.1: sodium hydroxide; water / ethanol / 4 h / 60 °C

5.2: 5 °C / pH 1

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 2.25 h / 0 - 20 °C

7.1: thionyl chloride / dichloromethane / 2 h / 0 - 20 °C

8.1: triethylamine; sodium iodide / ISOPROPYLAMIDE / 4 h / 110 °C

9.1: sodium hydroxide; water / ethanol / 2 h / 60 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.5 h / 20 °C

With sodium hydroxide; thionyl chloride; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium iodide; zinc(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; ethyl acetate; N,N-dimethyl-formamide; iso-butanol;