2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Base Information

Chemical Name:2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile
CAS No.:1610371-24-8
Molecular Formula:C₁₃H₁₁BrF₃N₃
Molecular Weight:346.15
Hs Code.:

Synonyms:2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Chemical Property of 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

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Technology Process of 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

There total 7 articles about 2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: potassium cyanide

: ((4S,5R)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)methyl methanesulfonate

: 1610371-24-8
2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: In dimethyl sulfoxide; at 40 ℃; for 9h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00982

Reference yield:

: ((4S,5R)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)methanol

: 1610371-24-8
2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

2: dimethyl sulfoxide / 40 °C / Cooling with ice

With triethylamine; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 622-88-8,41931-18-4
4-bromophenylhydrazine hydrochloride

: 1610371-24-8
2-((4S,5S)-1-(4-bromophenyl)-4-methyl-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 2.08 h / 20 °C

2: benzenesulfonyl chloride; N-ethyl-N,N-diisopropylamine / ethyl acetate / 0 - 20 °C

3: silver carbonate / 1,4-dioxane / 50 °C / Inert atmosphere

4: sodium tetrahydroborate / tetrahydrofuran; water / 4.08 h / 20 - 28.9 °C

5: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C

6: dimethyl sulfoxide / 40 °C / Cooling with ice

With sodium tetrahydroborate; triethylamine; N-ethyl-N,N-diisopropylamine; benzenesulfonyl chloride; silver carbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;