3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea

Base Information

• Chemical Name: 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea
• CAS No.: 1408074-87-2
• Molecular Formula: C₃₃H₃₃Cl₂N₇O
• Molecular Weight: 614.577

Synonyms:3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea

Chemical Property of 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea

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Technology Process of 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea

There total 4 articles about 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-amine (1408074-84-9) + Tert-butyl isocyanate (1609-86-5) → 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea (1408074-87-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 16h;

DOI:10.1021/jm301181r

Reference yield:

6-chloro-9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purine (686344-50-3) → 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea (1408074-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 16 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h

3: triethylamine / tetrahydrofuran / 16 h

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm301181r

Reference yield:

4-tert-butoxycarbonylamino-4-phenylpiperidine (178914-47-1) → 3-tert-butyl-1-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}urea (1408074-87-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / ethanol / 16 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h

3: triethylamine / tetrahydrofuran / 16 h

With triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm301181r

upstream raw materials:

tert-butyl N-{1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-yl}carbamate

1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-phenylpiperidin-4-amine

Tert-butyl isocyanate

6-chloro-9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purine

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