(S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate
CAS No.:1418307-20-6
Molecular Formula:C₁₉H₁₉BrN₄O₂
Molecular Weight:415.289
Hs Code.:

Synonyms:(S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

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Technology Process of (S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

There total 1 articles about (S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1418307-19-3
(S)-benzyl 2-(8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

: 1418307-20-6
(S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 87.0%

: 850568-25-1
4-(pyridin-2-yl-aminocarbonyl)benzeneboronic acid

: 1418307-20-6
(S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

: 1418307-21-7
(S)-benzyl 2-(8-methyl-1-(4-(pyridin-2-ylcarbamoyl)phenyl)imidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 140 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1418307-20-6
(S)-benzyl 2-(1-bromo-8-methylimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate

: 1418307-22-8
(S)-4-(8-methyl-3-(pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

2: hydrogen bromide; acetic acid; water / 2 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; hydrogen bromide; potassium carbonate; acetic acid; In 1,4-dioxane; water;