(S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid

Base Information

Chemical Name:(S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid
CAS No.:1338471-38-7
Molecular Formula:C₂₀H₁₈F₂N₂O₆
Molecular Weight:420.37
Hs Code.:

Synonyms:(S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid

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Chemical Property of (S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid

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Technology Process of (S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid

There total 5 articles about (S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: C₂₄H₂₆F₂N₂O₆

: 1338471-38-7
(S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; methoxybenzene; at 0 ℃;

Reference yield:

: 53117-14-9
ethyl 2-(2-methylanilino)-2-oxo-acetate

: 1338471-38-7
(S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / water

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 2 °C

3: Dess-Martin periodane / N,N-dimethyl-formamide / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane; methoxybenzene / 0 °C

With benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium hydroxide; In dichloromethane; water; methoxybenzene; N,N-dimethyl-formamide;

Reference yield:

: C₂₄H₂₈F₂N₂O₆

: 1338471-38-7
(S)-5-(2,6-difluorophenoxy)-3-[(2-methyl-phenylaminooxalyl)-amino]-4-oxo-pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / N,N-dimethyl-formamide / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane; methoxybenzene / 0 °C

With Dess-Martin periodane; trifluoroacetic acid; In dichloromethane; methoxybenzene; N,N-dimethyl-formamide;