(2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate
CAS No.:1027340-25-5
Molecular Formula:C₂₉H₄₅NO₄
Molecular Weight:471.681
Hs Code.:

Synonyms:(2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

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Chemical Property of (2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

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Technology Process of (2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

There total 1 articles about (2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 544711-70-8
(4R,5R)-5-allyl-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 1027340-25-5
(2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

Guidance literature:: With dmap; triethylamine;
DOI:10.1039/b800445e

Reference yield:

: 1027340-25-5
(2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

: ((2R,3R)-tert-butyl 2-allyl-5-hydroxy-3-((S)-1-(2,4,6-triisopropylphenyl)ethoxy)-pyrrolidine-1-carboxylate)

Guidance literature:: With lithium triethylborohydride;
DOI:10.1039/b800445e

Reference yield:

: 1027340-25-5
(2R,3R)-tert-butyl 2-allyl-5-oxo-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

: 1027340-26-6
(2R,3R)-tert-butyl 2-allyl-5-methoxy-3-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium triethylborohydride / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2: toluene-4-sulfonic acid / 3 h / 20 °C / Inert atmosphere

With lithium triethylborohydride; toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2014.12.002