6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

Base Information

Chemical Name:6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol
CAS No.:919298-91-2
Molecular Formula:C₂₉H₄₆O₅Si
Molecular Weight:502.767
Hs Code.:

6-benzyloxy-2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

Synonyms:6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

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Chemical Property of 6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

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Technology Process of 6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

There total 8 articles about 6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 919298-81-0
C₃₅H₆₀O₅Si₂

: 919298-91-2
6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 0 - 20 ℃; for 7h;
DOI:10.1021/ol062737k

Reference yield:

: 5,6-bis-(tert-butyl-dimethyl-silanyloxy)-3-hydroxy-2,4-dimethyl-hexanal

: 919298-91-2
6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄

2: 95 percent / MgSO₄; PPTS / toluene / 72 h / 80 °C

3: 90 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

4: 98 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 0 - 20 °C

5: 64 percent / p-TSA / methanol / 7 h / 0 - 20 °C

With sodium tetrahydroborate; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; magnesium sulfate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ol062737k

Reference yield:

: 6,7-bis-(tert-butyl-dimethyl-silanyloxy)-3,5-dimethyl-hept-1-en-4-ol

: 919298-91-2
6-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-3,5-dimethyl-hexan-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: OsO₄; NMO / 2-methyl-propan-2-ol; H₂O

2: NaIO₄ / acetone; H₂O

3: NaBH₄

4: 95 percent / MgSO₄; PPTS / toluene / 72 h / 80 °C

5: 90 percent / DIBAL-H / CH₂Cl₂ / -78 - 0 °C

6: 98 percent / NaHMDS / tetrahydrofuran; dimethylformamide / 0 - 20 °C

7: 64 percent / p-TSA / methanol / 7 h / 0 - 20 °C

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; magnesium sulfate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/ol062737k