methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate

Base Information

Chemical Name:methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate
CAS No.:1613730-42-9
Molecular Formula:C₁₅H₁₈F₃NO₂Si
Molecular Weight:329.394
Hs Code.:

Synonyms:methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate

Chemical Property:

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Technology Process of methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate

There total 4 articles about methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613730-41-8
methyl 4-amino-3-iodo-5-methyl-2-(trifluoromethyl)benzoate

: 1066-54-2
trimethylsilylacetylene

: 1613730-42-9
methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine; In toluene; at 70 ℃; for 3.5h; Inert atmosphere;

Reference yield:

: 1613730-40-7
methyl 4-amino-5-methyl-2-(trifluoromethyl)benzoate

: 1613730-42-9
methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; silver sulfate / ethanol / 7 h / 50 °C / Inert atmosphere

2: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 3.5 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; silver sulfate; triethylamine; triphenylphosphine; In ethanol; toluene;

Reference yield:

: 894796-87-3
methyl 4-amino-2-(trifluoromethyl)benzoate

: 1613730-42-9
methyl 4-amino-5-methyl-2-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: iodine; silver sulfate / ethanol / 0.25 h / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; 1,4-dioxane / 0.5 h / 65 °C / Inert atmosphere; Sealed tube

3: iodine; silver sulfate / ethanol / 7 h / 50 °C / Inert atmosphere

4: copper(l) iodide; triphenylphosphine; triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 3.5 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; silver sulfate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; toluene;