3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

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Chemical Name:3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine
CAS No.:1275586-45-2
Molecular Formula:C₅₃H₅₇N₆O₁₀P
Molecular Weight:969.044
Hs Code.:

Synonyms:3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

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Chemical Property of 3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

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Technology Process of 3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

There total 9 articles about 3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1275586-44-1
5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1275586-45-2
3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol200141v

Reference yield:

: 1275586-41-8
1-(3-nitrodibenzofuran-2-yl)ethaneamine

: 1275586-45-2
3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 90 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: pyridine / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol200141v

Reference yield:

: 1275586-42-9
3'-5'-O-di(tert-butyldimethylsilyl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

: 1275586-45-2
3'-O-(2-cyanoethoxy-N,N-diisopropylamin)phosphine-5'-O-(4,4'-dimethoxytrityl)-2-N-(1-(3-nitrodibenzofuran-2-yl))ethyl-2'-deoxycytosine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2: pyridine / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol200141v