N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

Base Information

Chemical Name:N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]
CAS No.:868845-09-4
Molecular Formula:C₂₇H₃₉N₁₁O₇
Molecular Weight:629.676
Hs Code.:

Synonyms:N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

Suppliers and Price of N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

Chemical Property:

Purity/Quality:: 95%;98%;99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

There total 23 articles about N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: cyclo[Arg-Gly-Asp-D-Phe-Lys]*AcOH

: 868845-09-4
N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

Guidance literature:: With copper(ll) sulfate pentahydrate; triflic azide; sodium hydroxide; In dichloromethane; water; tert-butyl alcohol; at 20 ℃; pH=10;
DOI:10.1055/s-0030-1258396

Reference yield:

: C₄₄H₆₃N₁₁O₁₀S

: 868845-09-4
N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

Guidance literature:: With 1,4-dithio-D,L-threitol; water; trifluoroacetic acid; In dichloromethane; ethyl acetate; at 20 ℃; for 0.5h;
DOI:10.1021/bc500034n

Reference yield:

: Asp(OBn)-D-Phe-Ot-Bu

: 868845-09-4
N-ε-azido cyclo[Arg-Gly-Asp-D-Phe-Lys]

Guidance literature:: Multi-step reaction with 10 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: diethylamine / dichloromethane / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: diethylamine / dichloromethane / 20 °C

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

6: dichloromethane / 0 - 20 °C

7: benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

8: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 20 °C

9: hydrogen fluoride; methoxybenzene / -78 - 0 °C

10: copper(ll) sulfate pentahydrate; triflic azide; sodium hydroxide / dichloromethane; water; tert-butyl alcohol / 20 °C / pH 10

With copper(ll) sulfate pentahydrate; triflic azide; palladium 10% on activated carbon; hydrogen fluoride; hydrogen; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; diethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1055/s-0030-1258396