2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

Base Information

Chemical Name:2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one
CAS No.:1616289-64-5
Molecular Formula:C₂₇H₂₈BrClN₂O₃
Molecular Weight:543.888
Hs Code.:

Synonyms:2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

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Chemical Property of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

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Technology Process of 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

There total 16 articles about 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1303445-99-9
2-(benzyloxy)-3-(chloromethyl)-4,6-dimethylpyridine

: 1616289-62-3
5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

: 1616289-64-5
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: 5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one; With potassium hexamethylsilazane; In 1,4-dioxane; at 20 ℃; for 0.5h;

2-(benzyloxy)-3-(chloromethyl)-4,6-dimethylpyridine; In 1,4-dioxane; at 100 ℃; for 5h;

Reference yield:

: 721959-71-3
2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

: 1616289-64-5
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

2.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

3.1: potassium hexamethylsilazane / 1,4-dioxane / 0.5 h / 20 °C

3.2: 5 h / 100 °C

With methanol; sodium tetrahydroborate; thionyl chloride; potassium hexamethylsilazane; In 1,4-dioxane; dichloromethane;

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 1616289-64-5
2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5-bromo-8-chloro-7-(propan-2-yloxy)-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver(l) oxide / toluene / 20 h / 110 °C

2.1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3.1: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

4.1: thionyl chloride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

5.1: potassium hexamethylsilazane / 1,4-dioxane / 0.5 h / 20 °C

5.2: 5 h / 100 °C

With methanol; sodium tetrahydroborate; thionyl chloride; potassium hexamethylsilazane; diisobutylaluminium hydride; silver(l) oxide; In 1,4-dioxane; dichloromethane; toluene;