(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Chemical Name:(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester
CAS No.:136484-94-1
Molecular Formula:C₃₂H₄₅N₅O₇
Molecular Weight:611.739
Hs Code.:

(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Synonyms:(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

There total 16 articles about (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: (S)-2-[3-(2-{2-[3-Amino-2-(4-benzyloxy-phenyl)-4-oxo-azetidin-1-yl]-acetylamino}-acetylamino)-2-oxo-4-phenyl-azetidin-1-yl]-4-methyl-pentanoic acid tert-butyl ester

: 136484-94-1
(D/L)-Tyr-Gly-Gly-(D/L)-Phe-(L)-Leu-OBu^t

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 50 ℃;
DOI:10.1246/cl.1981.1297

Reference yield:

: 123168-17-2
[(S)-2-(4-Benzyloxy-phenyl)-1-chlorocarbonyl-ethyl]-carbamic acid 2,7-di-tert-butyl-10,10-dioxo-9,10-dihydro-10λ⁶-thioxanthen-9-ylmethyl ester

: 136484-94-1
(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / 10percent aq. NaHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: palladium acetate, ammonium formate / 10percent Pd/C / CH₂Cl₂; methanol / 16 h / Ambient temperature

With palladium diacetate; ammonium formate; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo00286a019

Reference yield:

: 93962-35-7
(S)-2-((S)-2-{2-[2-(2,7-Di-tert-butyl-10,10-dioxo-9,10-dihydro-10λ⁶-thioxanthen-9-ylmethoxycarbonylamino)-acetylamino]-acetylamino}-3-phenyl-propionylamino)-4-methyl-pentanoic acid tert-butyl ester

: 136484-94-1
(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfoxide / 10 h / 75 - 80 °C

2: 41 percent / 10percent aq. NaHCO₃ / CH₂Cl₂ / 0.5 h / 0 °C

3: palladium acetate, ammonium formate / 10percent Pd/C / CH₂Cl₂; methanol / 16 h / Ambient temperature

With palladium diacetate; ammonium formate; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jo00286a019