2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile

Base Information

• Chemical Name: 2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile
• CAS No.: 1360057-23-3
• Molecular Formula: C₂₀H₁₆BrFN₂O₂
• Molecular Weight: 415.262
• Mol file: 1360057-23-3.mol

Synonyms:2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile

Chemical Property of 2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile

There total 2 articles about 2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.7%

2-(8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile (1360057-22-2) + 2,6-dibromobenzaldehyde (67713-23-9) → 2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile (1360057-23-3)

Guidance literature:

With copper(l) iodide; In dimethyl sulfoxide; at 110 ℃; for 24h;

DOI:10.1021/acs.jmedchem.8b01147

Reference yield:

→ 2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile (1360057-23-3)

Guidance literature:

Reference yield: 100.0%

2-(2-(3-bromo-2-formylphenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile (1360057-23-3) → 2-(2-(3-bromo-2-(hydroxymethyl)phenyl)-8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile

Guidance literature:

With sodium tetrahydroborate; In dichloromethane; isopropyl alcohol; at 0 - 20 ℃; for 0.5h;

DOI:10.1021/acs.jmedchem.8b01147

upstream raw materials:

2-(8-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-methylpropanenitrile

2,6-dibromobenzaldehyde