(4-fluorophenyl)-2-mercaptoacrylic acid

Base Information

• Chemical Name: (4-fluorophenyl)-2-mercaptoacrylic acid
• CAS No.: 29529-79-1
• Molecular Formula: C₉H₇FO₂S
• Molecular Weight: 198.218
• Mol file: 29529-79-1.mol

Synonyms:(4-fluorophenyl)-2-mercaptoacrylic acid

Chemical Property of (4-fluorophenyl)-2-mercaptoacrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-fluorophenyl)-2-mercaptoacrylic acid

There total 8 articles about (4-fluorophenyl)-2-mercaptoacrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

((4-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(4-methylpiperazin-1-yl)acetamide → (4-fluorophenyl)-2-mercaptoacrylic acid (29529-79-1)

Guidance literature:

((4-fluorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(4-methylpiperazin-1-yl)acetamide; With sodium hydroxide; at 60 ℃; for 0.75h;

With hydrogenchloride; In water;

DOI:10.1016/j.bmc.2018.02.043

Reference yield: 63.0%

5-(p-Fluorobenzylidene)-4-oxothiazolidine-2-thione (402-93-7) → (4-fluorophenyl)-2-mercaptoacrylic acid (29529-79-1)

Guidance literature:

5-(p-Fluorobenzylidene)-4-oxothiazolidine-2-thione; With sodium hydroxide; for 0.5h; Reflux;

With hydrogenchloride; In water;

DOI:10.1002/ejic.201300633

Reference yield:

4-fluorobenzalaniline (5676-81-3,102904-34-7) → (4-fluorophenyl)-2-mercaptoacrylic acid (29529-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / conc. HCl / ethanol / Heating

2: 5percent KOH / H₂O / Heating

With potassium hydroxide; hydrogenchloride; In ethanol; water;

DOI:10.1007/BF00503664

upstream raw materials:

5-(p-Fluorobenzylidene)-4-oxothiazolidine-2-thione

5-[(4-Fluoro-phenyl)-phenylamino-methyl]-3-phenyl-2-thioxo-thiazolidin-4-one

5-[(4-Fluoro-phenyl)-(3-nitro-phenylamino)-methyl]-3-phenyl-2-thioxo-thiazolidin-4-one

4-fluorobenzalaniline