(3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone

Base Information

Chemical Name:(3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone
CAS No.:1380336-30-0
Molecular Formula:C₂₅H₃₅N₅O
Molecular Weight:421.586
Hs Code.:

Synonyms:(3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone

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Chemical Property of (3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone

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Technology Process of (3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone

There total 7 articles about (3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: tert-butyl 4-benzoyl-2-(S-((4-((tert-butoxycarbonyl)amino)butyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazine-1-carboxylate

: 1380336-30-0
(3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: With water; trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2015.04.036

Reference yield:

: C₂₃H₃₈N₂O₄Si

: 1380336-30-0
(3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride; water / tetrahydrofuran / 3 h / 20 °C

2: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere

3: diisobutylaluminium hydride; sodium tris(acetoxy)borohydride / dichloromethane / 48 h / -78 - 20 °C

4: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C

5: water; trifluoroacetic acid / dichloromethane / 20 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; water; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 2: |Swern Oxidation;
DOI:10.1016/j.bmcl.2015.04.036

Reference yield:

: tert-butyl 4-benzoyl-2-(hydroxymethyl)piperazine-1-carboxylate

: 1380336-30-0
(3-(S-((4-aminobutyl)((S)-5,6,7,8-tetrahydroquinolin-8-yl)amino)methyl)piperazin-1-yl)(phenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 3 h / -78 - 0 °C / Inert atmosphere

2: diisobutylaluminium hydride; sodium tris(acetoxy)borohydride / dichloromethane / 48 h / -78 - 20 °C

3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C

4: water; trifluoroacetic acid / dichloromethane / 20 °C

With oxalyl dichloride; water; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In dichloromethane; 1: |Swern Oxidation;
DOI:10.1016/j.bmcl.2015.04.036