[(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

Base Information

Chemical Name:[(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate
CAS No.:1012860-23-9
Molecular Formula:C₃₇H₃₂ClF₃N₄O₄
Molecular Weight:689.134
Hs Code.:

[(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

Synonyms:[(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

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Chemical Property of [(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

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Technology Process of [(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

There total 1 articles about [(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1012860-25-1
2-[(3R)-3-(hydroxymethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]-N-[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]acetamide

: 16588-69-5
4-chloro-2-trifluoromethylphenylisocyanate

: 1012860-23-9
[(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

Guidance literature:: In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm701141u

Reference yield: 99.0%

: 1012860-23-9
[(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

: 78-94-4,25038-87-3
methyl vinyl ketone

: (4-chloro-2-trifluoromethyl-phenyl)-carbamic acid (3R)-2-oxo-1-{[4-oxo-(1S)-1-phenethylpent-2-enylcarbamoyl]-methyl}-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl ester

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 100 ℃; for 1h; Microwave irradiation;
DOI:10.1021/jm900047j

Reference yield: 99.0%

: 1012860-23-9
[(3R)-2-oxo-1-(2-oxo-2-{[(1S)-1-(2-phenylethyl)prop-2-en-1-yl]amino}ethyl)-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]methyl[4-chloro-2-(trifluoromethyl)phenyl]carbamate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: (4S)-4-{2-[3-(4-chloro-2-trifluoromethyl-phenylcarbamoyloxymethyl)-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl]-acetylamino}-6-phenyl-hex-2-enoic acid methyl ester

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 100 ℃; for 1h; Microwave irradiation;
DOI:10.1021/jm900047j