5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol

Base Information

• Chemical Name: 5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol
• CAS No.: 1203608-54-1
• Molecular Formula: C₁₆H₉BrF₄N₂
• Molecular Weight: 385.158
• Mol file: 1203608-54-1.mol

Synonyms:5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol

Chemical Property of 5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol

Chemical Property:

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Technology Process of 5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol

There total 1 articles about 5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one (1203608-46-1) + 4-(trifluoromethyl)phenylhydrazine hydrochloride (2923-56-0) → 5-(2-bromo-4-fluorophenyl)-1-(4-trifluoromethylphenyl)pyrazol (1203608-54-1)

Guidance literature:

With sodium carbonate; acetic acid; In methanol; water; at 135 ℃; for 2h; pH=4; regioselective reaction;

DOI:10.1021/jo902257j

upstream raw materials:

(E)-1-(2-bromo-4-fluorophenyl)-3-(N,N-dimethylamino)-2-propen-1-one

4-(trifluoromethyl)phenylhydrazine hydrochloride