Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester
CAS No.:808109-76-4
Molecular Formula:C₂₄H₂₈O₈S
Molecular Weight:476.548
Hs Code.:

Synonyms:Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

There total 5 articles about Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 98-59-9
p-toluenesulfonyl chloride

: 808109-38-8
(4aS,6S,7S,8S,8aR)-6-Allyl-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

: 808109-76-4
Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: With pyridine; at 20 ℃;
DOI:10.1016/j.bmcl.2004.08.068

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 808109-76-4
Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / p-TsOH / dimethylformamide / 20 °C

2: 71 percent / pyridine / 20 °C

With pyridine; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.08.068

Reference yield:

: 188783-40-6
α/β‐L‐glucopyranosyl‐1,2,3,4,5‐pentaacetate

: 808109-76-4
Toluene-4-sulfonic acid (4aS,6S,7S,8R,8aR)-6-allyl-8-hydroxy-2-(4-methoxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / BF₃*Et₂O / acetonitrile / 80 °C

2: 84 percent / NaOMe / methanol / 20 °C

3: 90 percent / p-TsOH / dimethylformamide / 20 °C

4: 71 percent / pyridine / 20 °C

With pyridine; boron trifluoride diethyl etherate; sodium methylate; toluene-4-sulfonic acid; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2004.08.068