rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

Base Information

Chemical Name:rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide
CAS No.:930283-13-9
Molecular Formula:C₂₉H₂₈Cl₂N₄O₃
Molecular Weight:551.472
Hs Code.:

Synonyms:rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

Suppliers and Price of rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

There total 5 articles about rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1-(4-benzyloxyphenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid chloride

: 75332-31-9,151666-28-3
3-hydroxy-1-aminopiperidine

: 930283-13-9
rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

Guidance literature:: 1-(4-benzyloxyphenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid chloride; 3-hydroxy-1-aminopiperidine; With triethylamine; In tetrahydrofuran; dichloromethane; at -20 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; at 40 ℃; for 0.25h;

Reference yield:

: 866598-55-2
N-(4-(benzyloxy)phenyl)-2,4-dichlorobenzamidine

: 930283-13-9
rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 0.17 h

1.2: 67 h / 20 °C

2.1: water; potassium hydroxide / methanol / 2 h / Reflux

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

4.1: triethylamine / tetrahydrofuran; dichloromethane / -20 - 20 °C / Inert atmosphere

With oxalyl dichloride; water; potassium carbonate; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/acs.jmedchem.7b00861

Reference yield:

: 866598-57-4
1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-5-methyl-1H-imidazole-4-carboxylic acid

: 930283-13-9
rac-1-(4-(benzyloxy)phenyl)-2-(2,4-dichlorophenyl)-N-(3-hydroxypiperidin-1-yl)-5-methyl-1H-imidazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / Reflux

2: triethylamine / tetrahydrofuran; dichloromethane / -20 - 20 °C / Inert atmosphere

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/acs.jmedchem.7b00861