((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Base Information

Chemical Name:((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate
CAS No.:1581704-32-6
Molecular Formula:C₃₄H₃₃F₆N₄O₉P
Molecular Weight:786.622
Hs Code.:

((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Synonyms:((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

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Chemical Property of ((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

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Technology Process of ((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

There total 4 articles about ((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1581704-56-4
((S)-3-((2R,3S)-3-Carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanamido)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)methyl2-(4-((di-tert-butoxyphosphoryl)oxy)phenyl)acetate

: 1581704-32-6
((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;

Reference yield:

: 1581704-55-3
(2R,3S)-N₁-((S)-1-(chloromethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

: 1581704-32-6
((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

2: hydrogenchloride / dichloromethane; diethyl ether / 8 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; caesium carbonate; sodium iodide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1401066-80-5
(2R,3S)-N-((3S)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2,3-bis(3,3,3-trifluoropropyl)succinamide

: 1581704-32-6
((3S)-3-(((2R,3S)-3-carbamoyl-6,6,6-trifluoro-2-(3,3,3-trifluoropropyl)hexanoyl)amino)2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl)methyl(4-(phosphonooxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: N,N-diethylethanamine hydrochloride / dichloromethane / 0.08 h / 20 °C

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: caesium carbonate; sodium iodide / N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride / dichloromethane; diethyl ether / 8 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; N,N-diethylethanamine hydrochloride; caesium carbonate; sodium iodide; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;