2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile

Base Information

Chemical Name:2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile
CAS No.:1422022-06-7
Molecular Formula:C₂₁H₁₉FN₂O₂
Molecular Weight:350.392
Hs Code.:

Synonyms:2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile

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Chemical Property of 2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile

Chemical Property:

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Technology Process of 2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile

There total 5 articles about 2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1422022-05-6
2-bromo-3’-fluoro-4’-hydroxy-5-propylbiphenyl-3-carbonitrile

: 1422022-06-7
2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile

Guidance literature:: With palladium diacetate; potassium carbonate; ruphos; In water; toluene; at 140 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 39263-32-6
2-amino-5-bromobenzonitrile

: 1422022-06-7
2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; ruphos; potassium carbonate / water; toluene / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

2: iodine; silver(II) sulfate / ethanol / 1 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; ethanol; 1,2-dimethoxyethane / 0.33 h / 130 °C / Inert atmosphere; Microwave irradiation

4: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 °C

5: palladium diacetate; ruphos; potassium carbonate / water; toluene / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; tert.-butylnitrite; silver(II) sulfate; iodine; palladium diacetate; potassium carbonate; copper(ll) bromide; ruphos; In 1,2-dimethoxyethane; ethanol; water; toluene; acetonitrile; 1: |Suzuki Coupling / 3: |Suzuki Coupling / 5: |Suzuki Coupling;

Reference yield:

: 1422022-04-5
2-amino-3'-fluoro-4^,-hydroxy-5-propylbiphenyl-3-carbonitrile

: 1422022-06-7
2-(3,5-dimethylisoxazol-4-yl)-3'-fluoro-4'-hydroxy-5-propylbiphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 °C

2: palladium diacetate; ruphos; potassium carbonate / water; toluene / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With tert.-butylnitrite; palladium diacetate; potassium carbonate; copper(ll) bromide; ruphos; In water; toluene; acetonitrile; 2: |Suzuki Coupling;