(+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide

Base Information

Chemical Name:(+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide
CAS No.:467457-17-6
Molecular Formula:C₂₂H₃₁N₃O₆S₂
Molecular Weight:497.637
Hs Code.:

Synonyms:(+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide

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Technology Process of (+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide

There total 2 articles about (+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 98-59-9
p-toluenesulfonyl chloride

: 467457-13-2
(3S)-N-(4-aminobutyl)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}butanamide

: 467457-17-6
(+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E

Reference yield:

: 147228-21-5
(S)-4-<(tolylsulfonyl)amino>-γ-butyrolactone

: 467457-17-6
(+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Cu(OAc)2 / CHCl₃ / 6 h / Heating

2: 81 percent / Et₃N / dimethylformamide / 5 h / 20 °C

With triethylamine; copper diacetate; In chloroform; N,N-dimethyl-formamide;
DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E

Reference yield: 90.0%

: 5469-66-9
propane-1,3-diol ditosylate

: 467457-17-6
(+)-(3S)-4-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}-N-(4-{[(4-methylphenyl)sulfonyl]amino}butyl)butanamide

: (+)-(4S)-4-(hydroxymethyl)-5,9-bis[(4-methylphenyl)sulfonyl]-1,5,9-triazacyclotridecan-2-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 24h;
DOI:10.1002/1522-2675(200206)85:6<1742::AID-HLCA1742>3.0.CO;2-E