Benzo(b)thiophen-3-amine, 2-nitro-N-phenyl-

Base Information

• Chemical Name: Benzo(b)thiophen-3-amine, 2-nitro-N-phenyl-
• CAS No.: 10133-37-6
• Molecular Formula: C14H10 N2 O2 S
• Molecular Weight: 270.312
• DSSTox Substance ID: DTXSID90143854
• Nikkaji Number: J514.196F
• Mol file: 10133-37-6.mol

Synonyms:Benzo(b)thiophen-3-amine, 2-nitro-N-phenyl-;2-nitro-N-phenyl-1-benzothiophen-3-amine;BRN 1319162;10133-37-6;2-Nitro-N-phenylbenzo(b)thiophen-3-amine;C14H10N2O2S;2-nitro-N-phenylbenzo[b]thiophen-3-amine;SCHEMBL15443296;ZQHXXAOMTMKWSQ-UHFFFAOYSA-;DTXSID90143854;LS-41113;N-Phenyl-2-nitro-3-benzo[b]thiophenamine;AA-516/31408025

Chemical Property of Benzo(b)thiophen-3-amine, 2-nitro-N-phenyl-

Chemical Property:

• Vapor Pressure: 2.2E-08mmHg at 25°C
• Boiling Point: 452.7°C at 760 mmHg
• Flash Point: 227.6°C
• Density: 1.415g/cm³
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 270.04629874
• Heavy Atom Count: 19
• Complexity: 328

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=C(SC3=CC=CC=C32)[N+](=O)[O-]

Technology Process of Benzo(b)thiophen-3-amine, 2-nitro-N-phenyl-

There total 4 articles about Benzo(b)thiophen-3-amine, 2-nitro-N-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-bromo-2-nitro-1-benzothiophene (17402-78-7) + aniline (62-53-3) → 2-nitro-3-N-phenylamino-benzothiophene (10133-37-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 120 ℃; for 0.75h;

DOI:10.1016/S0040-4020(01)00875-4

Reference yield:

3-bromo-2-nitro-1-benzothiophene (17402-78-7) + aniline (62-53-3) → 2-nitro-3-N-phenylamino-benzothiophene (10133-37-6) + N-(3-nitrobenzo[b]thiophene-2-yl)aniline

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)00875-4

Reference yield:

3-Bromothianaphthene (7342-82-7) → 2-nitro-3-N-phenylamino-benzothiophene (10133-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride / dichloromethane / 0.17 h / 0 °C

1.2: 0.5 h / 0 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 8 h / 120 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane;

upstream raw materials:

3-bromo-2-nitro-1-benzothiophene

aniline

Benzo[b]thiophene

3-Bromothianaphthene