4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal

Base Information

• Chemical Name: 4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal
• CAS No.: 128990-84-1
• Molecular Formula: C₁₈H₂₃NO₂S₃
• Molecular Weight: 381.584
• Mol file: 128990-84-1.mol

Synonyms:4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal

Chemical Property of 4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal

There total 1 articles about 4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-2-phenylthioethane (4837-01-8) + 4-acetonyl-2,6-piperidinedione (126523-27-1) → 4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal (128990-84-1)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 0 deg C, 1 h; 2.) 3 h, RT;

DOI:10.1016/S0040-4020(01)85805-1

Reference yield: 89.0%

4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal (128990-84-1) → 4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione (128990-86-3)

Guidance literature:

With mercury dichloride; mercury(II) oxide; In methanol; water; for 3h; Heating;

DOI:10.1016/S0040-4020(01)85805-1

Reference yield:

4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione ethylenedithioacetal (128990-84-1) → 4-(2-methyl-3-indolyl)-1-<2-(phenylthio)ethyl>-2,6-piperidinedione (128990-94-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / HgCl₂/HgO / methanol; H₂O / 3 h / Heating

2: ethanol / 3 h / Heating

3: 22 percent / PPA / 1 h / 80 °C

With mercury dichloride; mercury(II) oxide; In methanol; ethanol; water;

DOI:10.1016/S0040-4020(01)85805-1

upstream raw materials:

1-bromo-2-phenylthioethane

4-acetonyl-2,6-piperidinedione

Downstream raw materials:

4-acetonyl-1-<2-(phenylthio)ethyl>-2,6-piperidinedione

4-(2-methyl-3-indolyl)-1-<2-(phenylthio)ethyl>-2,6-piperidinedione

N-<2-(phenylthio)ethyl>-4-oxo-1,2,3,4-tetrahydro-2-carbazoleacetamide

4-[2-(Phenyl-hydrazono)-propyl]-1-(2-phenylsulfanyl-ethyl)-piperidine-2,6-dione