{1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane

Base Information

Chemical Name:{1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane
CAS No.:1333473-54-3
Molecular Formula:C₃₁H₄₆O₇Si
Molecular Weight:558.788
Hs Code.:

Synonyms:{1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane

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Chemical Property of {1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane

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Technology Process of {1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane

There total 6 articles about {1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 1333473-53-2
(3S,7S)-5-(tert-butyldimethylsilyloxy)nonane-1,3,7,9-tetraol

: 1333473-54-3
{1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 3h; diastereoselective reaction;
DOI:10.1021/jo2012658

Reference yield:

: 1333473-52-1
(3R,7R)-1,9-bis[(S)-4-tert-butyl-2-thioxothiazolidin-3-yl]-5-(tertbutyldimethylsilyloxy)-3,7-dihydroxynonane-1,9-dione

: 1333473-54-3
{1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 0 - 20 °C

1.2: 2.5 h

2.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C

With sodium tetrahydroborate; pyridinium p-toluenesulfonate; In ethanol; dichloromethane;
DOI:10.1021/jo2012658

Reference yield:

: 7250-55-7
dimethyl 3-hydroxypentanedioate

: 1333473-54-3
{1,3-bis[(2S,4S)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-2-yloxy}(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 14 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / hexanes; diethyl ether / 1.83 h / -78 °C

2.2: 3 h / 20 °C / Saturated solution

3.1: phenylborondichloride; (-)-sparteine / dichloromethane / 0.5 h / 0 - 20 °C

3.2: 16.17 h / 0 - 20 °C

3.3: 0.25 h / 20 °C / Cooling with ice

4.1: sodium tetrahydroborate / ethanol / 0 - 20 °C

4.2: 2.5 h

5.1: pyridinium p-toluenesulfonate / dichloromethane / 3 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; phenylborondichloride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; (-)-sparteine; In hexanes; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo2012658