2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole

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Chemical Name:2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole
CAS No.:1279103-83-1
Molecular Formula:C₂₀H₁₄F₅N₃
Molecular Weight:391.343
Hs Code.:

Synonyms:2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole

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Chemical Property of 2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole

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Technology Process of 2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole

There total 6 articles about 2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1279105-83-7
trifluoro-methanesulfonic acid 2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl ester

: 1279106-72-7
2-(2,6-Difluoro-phenyl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indole

: 1279103-83-1
2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 100 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1188072-92-5
5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279103-83-1
2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 14 h / 100 °C / Inert atmosphere

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; acetonitrile;

Reference yield:

: 13670-99-0
2,6-difluoroacetophenone

: 1279103-83-1
2-(2,6-Difluoro-phenyl)-5-(2-ethyl-5-trifluoromethyl-2H-pyrazol-3-yl)-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / ethanol / 16 h / 25 °C

2: polyphosphoric acid / 2 h / 130 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 14 h / 100 °C / Inert atmosphere

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; acetonitrile;